In this review, we provide an updated summary on colistin pharmacokinetics and
pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment …

Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the
treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria …

Carbapenem-resistant Acinetobacter baumannii (CRAB) is one of the most common causes
of nosocomial infections in critically ill patients. Colistin methanesulfonate (CMS), an inactive …

'Old'colistin and polymyxin B are increasingly used as last-line therapy against multidrug-
resistant Gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and …

Abstract Purpose of Review The polymyxins are one of the last line antimicrobial classes to
retain activity against multidrug-resistant Gram-negative bacilli. However, with the increased …

Background The pharmacokinetic/pharmacodynamic (PK/PD) relationship for polymyxin B
against Klebsiella pneumoniae infections is not known. Methods Dose-fractionation studies …

Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …

The emergence of resistant to carbapenems Gram-negative bacteria (CR GNB) has severely
challenged antimicrobial therapy. Many CR GNB isolates are only susceptible to …

Abstract (See the Editorial Commentary by Falagas and Rafailidis, on pages 681–3.)
Background. Experience with intravenous and aerosolized forms of colistin for the treatment …

Increasing incidence of resistance of gram-negative bacteria against even newer antibiotic
including carbapenem has generated interest in the old antibiotic colistin, which are being …