As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Astrocytes are the largest group of glial cells in the brain and participate in several essential
functions of the central nervous system (CNS). Disruption of their normal physiological …

Lysosomal failure underlies pathogenesis of numerous congenital neurodegenerative
disorders and is an early and progressive feature of Alzheimer's disease (AD) pathogenesis …

Metals serve important roles in the human body, including the maintenance of cell structure
and the regulation of gene expression, the antioxidant response, and neurotransmission …

The development of Alzheimer's disease (AD) is influenced by several events, among which
the dysregulation of cholesterol metabolism in the brain plays a major role. Maintenance of …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the main cause of
dementia. The disease is among the leading medical concerns of the modern world …

A growing bulk of evidence suggests that cholesterol oxidation products, known as
oxysterols, are potentially involved in the pathogenesis of major chronic diseases, including …

The burden of neurological and neuropsychiatric disorders continues to grow with significant
impacts on human health and social economy worldwide. Increasing clinical and preclinical …

Background Despite accumulating epidemiological studies support that diabetes increases
the risk of Alzheimer's disease (AD), the causal associations between diabetes and AD …