In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several
important cellular processes in the gastric epithelium including proliferation, apoptosis …

Abetted by widespread usage of acid-suppressing proton pump inhibitors (PPIs), the
mitogenic actions of the peptide hormone gastrin are being revisited as a recurring theme in …

Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are
involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered …

In 1905, a Cambridge physiologist, John Sydney Edkins, initially identified a hormone
responsible of gastric acid secretion, which he called gastric secretin, or gastrin. While …

Animal models have greatly enriched our understanding of the molecular mechanisms of
numerous types of cancers. Gastric cancer is one of the most common cancers worldwide …

Highlights•Gastrin promotes proximal gastric cancer development but inhibits distal cancer
development.•PPI use increases serum gastrin levels and may affect gastric …

Gastric acid secretion (i) facilitates digestion of protein as well as absorption of
micronutrients and certain medications,(ii) kills ingested microorganisms, including …

Vagotomy reduces gastric acid secretion and was therefore introduced as a surgical
treatment for peptic ulcers in the 1970s. Later, it was replaced by acid reducing medication …

Background & Aims: Apart from its importance as an acid secretogogue, the role of
histamine as a downstream target of gastrin has not been fully explored. Previous studies …

We have previously reported that the dendritic cell (DC) functional index cytokine interleukin‐
12 was significantly decreased in colorectal carcinoma (CRC) tissues. In this study, the DC …