The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation

VT Ho, RJ Soiffer - Blood, The Journal of the American Society …, 2001 - ashpublications.org
Despite significant progress in the past 20 years, graft-versus-host disease (GVHD) remains
a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell …

Establishment of complete and mixed donor chimerism after allogeneic lymphohematopoietic transplantation: recommendations from a workshop at the 2001 Tandem …

JH Antin, R Childs, AH Filipovich, S Giralt… - Biology of Blood and …, 2001 - tctjournal.org
Approaches to the measurement of lymphohematopoietic chimerism have evolved from
laboratory research to important clinical tools. However, there has been no logical …

Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction

M Alizadeh, M Bernard, B Danic… - Blood, The Journal …, 2002 - ashpublications.org
We have developed a real-time quantitative polymerase chain reaction (PCR) assay using
TaqMan technology (Applied Biosystems, Foster City, CA) for monitoring donor cell …

Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of …

S Mackinnon, EB Papadopoulos, MH Carabasi… - 1995 - ashpublications.org
Infusions of large numbers (> 10 (8)/kg) of donor leukocytes can induce remissions in
patients with chronic myeloid leukemia (CML) who relapse after marrow transplantation. We …

Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia

MC Walters, M Patience, W Leisenring… - Biology of Blood and …, 2001 - tctjournal.org
A multicenter investigation of allogeneic bone marrow transplantation for children with sickle
cell disease was conducted that included 27 European and North American transplant …

In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation

PD Kottaridis, DW Milligan, R Chopra… - Blood, The Journal …, 2000 - ashpublications.org
A novel nonmyeloablative conditioning regimen was investigated in 44 patients with
hematologic malignancies. The median patient age was 41 years. Many of the patients had …

Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses

R Childs, E Clave, N Contentin… - Blood, The Journal …, 1999 - ashpublications.org
Nonmyeloablative allogeneic stem cell transplantation has recently been explored as a
safer alternative to conventional high-dose transplant regimens. Although a high incidence …

How and when should we monitor chimerism after allogeneic stem cell transplantation?

P Bader, D Niethammer, A Willasch… - Bone marrow …, 2005 - nature.com
Chimerism analysis has become an important tool for the peri-transplant surveillance of
engraftment. It offers the possibility to realize impending graft rejection and can serve as an …

Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen

R Chakraverty, K Peggs, R Chopra… - Blood, The Journal …, 2002 - ashpublications.org
A nonmyeloablative conditioning regimen was investigated in 47 patients with
hematological malignancy receiving allogeneic progenitor cells from matched, unrelated …

Kinetics of engraftment in patients with hematologic malignancies given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning

F Baron, JE Baker, R Storb, TA Gooley, BM Sandmaier… - Blood, 2004 - ashpublications.org
We analyzed the kinetics of donor engraftment among various peripheral blood cell
subpopulations and their relationship to outcomes among 120 patients with hematologic …