While the phenomenon of polyadenylation has been well-studied, the dynamics of poly (A)
tail size and its impact on transcript function and cell biology are less well-appreciated. The …

Poly (A) tails are 3′ modifications of eukaryotic mRNAs that are important in the control of
translation and mRNA stability. We identified hundreds of mouse liver mRNAs that exhibit …

The addition of a poly (A)-tail to the 3′ termini of RNA molecules influences stability,
nuclear export, and efficiency of translation. In the cytoplasm, dynamic changes in the length …

Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially
complementary target sites in the 3′ untranslated region (UTR) of messenger RNA (mRNA) …

A major objective of systems biology is to quantitatively integrate multiple parameters from
genome-wide measurements. To integrate gene expression with dynamics in poly (A) tail …

TDP-43 is an RNA-binding protein involved in several steps of mRNA metabolism including
transcription, splicing and stability. It is also involved in ALS and FTD, neurodegenerative …

Thiamine pyrophosphate (TPP), an essential co‐factor for all species, is biosynthesised
through a metabolically expensive pathway regulated by TPP riboswitches in bacteria, fungi …

Polyadenylation of mRNA leads to increased protein expression in response to diverse
stimuli, but it is difficult to identify mRNAs that become polyadenylated in living cells. Here …

Similar to eukaryotic mRNA, the positive-strand coronavirus genome of~ 30 kilobases is 5'-
capped and 3'-polyadenylated. It has been demonstrated that the length of the coronaviral …

We have previously shown that ARG2 expression was increased in most malignant thyroid
tumors, but absent in benign lesions and normal tissues. Small interfering RNA knockdown …