Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …

Make It Less difficile: Understanding Genetic Evolution and Global Spread of Clostridioides difficile

M Mengoli, M Barone, M Fabbrini, F D'Amico, P Brigidi… - Genes, 2022 - mdpi.com
Clostridioides difficile is an obligate anaerobic pathogen among the most common causes of
healthcare-associated infections. It poses a global threat due to the clinical outcomes of …

Targeting the Gut Microbiota and Host Immunity with a Bacilli-Species Probiotic during Antibiotic Exposure in Mice

D Shapiro, FR Kapourchali, A Santilli, Y Han… - Microorganisms, 2022 - mdpi.com
Antibiotic therapy is necessary for the treatment of bacterial infections; however, it can also
disrupt the balance and function of commensal gut microbes and negatively affect the host …

[HTML][HTML] Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection

Z Zang, C Zhang, KJ Park, DA Schwartz, R Podicheti… - bioRxiv, 2024 - ncbi.nlm.nih.gov
To overtake competitors, microbes produce and secrete secondary metabolites that kill
neighboring cells and sequester nutrients. This natural product-mediated competition likely …

Clostridium perfringens strains proliferate to high counts in the broiler small intestinal tract, in accordance with necrotic lesion severity, and sporulate in the distal …

M Hustá, S Tretiak, R Ducatelle, F Van Immerseel… - Veterinary …, 2023 - Elsevier
Clostridium (C.) perfringens is the causative agent of necrotic enteritis (NE), an important
enteric disease in poultry. Although a variety of virulence factors have been identified and as …

[HTML][HTML] fliL基因显著影响艰难拟梭菌运动功能及产孢能力

鲍江舰, 杨君仪, 邵瑞瑞, 张婷, 廖健, 程玉梅… - 生物工程 …, 2023 - cjb.ijournals.cn
鞭毛基底体相关FliL 家族蛋白(flagellar basal body-associated FliL family protein, fliL)
基因编码FliL 蛋白, FliL 是一种与鞭毛基体相结合的单跨膜蛋白. 为研究艰难拟梭菌fliL 基因功能 …

Association of Single Nucleotide Polymorphisms in Nucleotide-Binding Domain Leucine-Rich Repeat Protein 1 with Clostridioides difficile Colonization or Infection

BY Tsai, PJ Tsai, CC Lee, CW Chiu, YH Lai… - Infection and Drug …, 2023 - Taylor & Francis
Introduction Nucleotide-binding domain leucine-rich repeat protein (NLRP) is critical in the
inflammasome-activation pathway, which is important for host survival and the clearance of …

Impacts of Corticosteroid Therapy at Acute Stage of Hospital-Onset Clostridioides difficile Infections

CC Lee, JC Lee, CW Chiu, PJ Tsai… - Infection and Drug …, 2022 - Taylor & Francis
Introduction The influence of corticosteroid therapy before or after the onset of Clostridioides
difficile infections (CDIs) on the clinical outcomes of adults with hospital-onset CDIs was …

[HTML][HTML] Reappraisal of the clinical role of metronidazole therapy for Clostridioides difficile infection in Taiwan: A multicenter prospective study

JC Lee, CC Lee, CW Chiu, PJ Tsai, PR Hsueh… - Journal of the Formosan …, 2022 - Elsevier
Background/Purpose Although metronidazole is not recommended to treat Clostridioides
difficile infection (CDI) in Western countries, it was still to be recommended for the treatment …

Risk Factors and Clinical Impact of Carbapenem-Resistant Enterobacterales Coinfections Among Hospitalized Patients with Clostridioides difficile Infection

CC Lee, CW Chiu, JC Lee, PJ Tsai… - Infection and Drug …, 2022 - Taylor & Francis
Introduction The risk factors and clinical impact of carbapenem-resistant Enterobacterales
(CRE) coinfection among hospitalized patients with Clostridioides difficile infection (CDI) …