Background: Renal repair is closely related to the prognosis of acute kidney injury (AKI) and
has attracted increasing attention in the research field. However, there is a lack of a …

Epidemiological findings indicate that acute kidney injury (AKI) increases the risk for chronic
kidney disease (CKD), although the molecular mechanism remains unclear. Genetic fate …

The immune system is an important guardian of tissue homeostasis. In response to injury,
resident and infiltrating immune cells orchestrate all phases of danger control, resolution of …

Background: Chronic kidney disease (CKD) is one of the most common diseases in adult
age, and it is typical of older adults. Recent data suggest that almost half of the elders have …

Generation of kidney organoids using autologous kidney stem cells represents an attractive
strategy for treating and potentially replacing the failing kidneys. However, whether adult …

Diabetic nephropathy (DN) has been introduced as one of the main microvascular
complications in diabetic patients, the most common cause of end-stage renal disease …

PAX-2 is a transcription factor that controls the development of the kidney, organs deriving
from the mesonephric (Wolffian) duct, and those related to the Müllerian duct. Although PAX …

Recovery from acute kidney injury requires regeneration of tubule cells. Because calcineurin
induces nuclear transport of NFATc proteins, whose expression pattern correlates with the …

We recently developed a therapeutic biopolymer composed of an elastin-like polypeptide
(ELP) fused to vascular endothelial growth factor (VEGF) and showed long-term …

The potential role of stem cells in the repair of glomerular and tubular injury is under
intensive investigation. Several studies have addressed the role of endogenous bone …