[HTML][HTML] Pathophysiology of acute kidney injury
DP Basile, MD Anderson, TA Sutton - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …
Pathophysiology of ischemic acute kidney injury
AA Sharfuddin, BA Molitoris - Nature Reviews Nephrology, 2011 - nature.com
Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …
Differentiated kidney epithelial cells repair injured proximal tubule
Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …
Mechanisms of tubulointerstitial fibrosis
M Zeisberg, EG Neilson - Journal of the American Society of …, 2010 - journals.lww.com
The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis.
Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in …
Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in …
[HTML][HTML] Cell death in the kidney
G Priante, L Gianesello, M Ceol, D Del Prete… - International journal of …, 2019 - mdpi.com
Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …
Beyond tissue injury—damage-associated molecular patterns, Toll-like receptors, and inflammasomes also drive regeneration and fibrosis
HJ Anders, L Schaefer - Journal of the American Society of …, 2014 - journals.lww.com
Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …
[PDF][PDF] Intrinsic epithelial cells repair the kidney after injury
Understanding the mechanisms of nephron repair is critical for the design of new therapeutic
approaches to treat kidney disease. The kidney can repair after even a severe insult, but …
approaches to treat kidney disease. The kidney can repair after even a severe insult, but …
Repair of injured proximal tubule does not involve specialized progenitors
BD Humphreys, S Czerniak… - Proceedings of the …, 2011 - National Acad Sciences
Recently we have established that the kidney tubular epithelium is repaired by surviving
epithelial cells. It is not known, however, whether a population of intratubular adult …
epithelial cells. It is not known, however, whether a population of intratubular adult …
Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds
EA Ross, MJ Williams, T Hamazaki… - Journal of the …, 2009 - journals.lww.com
The scarcity of transplant allografts for diseased organs has prompted efforts at tissue
regeneration using seeded scaffolds, an approach hampered by the enormity of cell types …
regeneration using seeded scaffolds, an approach hampered by the enormity of cell types …
[HTML][HTML] Role of Oct4 in the early embryo development
G Wu, HR Schöler - Cell Regeneration, 2014 - Springer
Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction
with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem …
with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem …