Validation of biomarkers of aging

M Moqri, C Herzog, JR Poganik, K Ying, JN Justice… - Nature medicine, 2024 - nature.com
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

Biomarkers of aging for the identification and evaluation of longevity interventions

M Moqri, C Herzog, JR Poganik, J Justice, DW Belsky… - Cell, 2023 - cell.com
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

From biological aging to functional decline: A narrative review of insights into chronic inflammation and intrinsic capacity

X Li, L Ma - Ageing Research Reviews, 2023 - Elsevier
Intrinsic capacity is the sum of an individual's physical and mental capacities, which helps
determine functional ability. Intrinsic capacity decline is an important predictor of adverse …

Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults

WH Lu, S Guyonnet, LO Martinez, A Lucas, A Parini… - GeroScience, 2023 - Springer
Intrinsic capacity (IC), the composite of physical and mental capacities, declines with age at
different rates and patterns between individuals. We aimed to investigate the association …

Reference centiles for intrinsic capacity throughout adulthood and their association with clinical outcomes: a cross-sectional analysis from the INSPIRE-T cohort

WH Lu, Y Rolland, S Guyonnet, P de Souto Barreto… - Nature Aging, 2023 - nature.com
Intrinsic capacity (IC), a function-centered construct, is defined as the composite of all
physical and mental capacities of an individual. IC and surrounding environmental factors …

Subjective age and the association with intrinsic capacity, functional ability, and health among older adults in Norway

EM Langballe, V Skirbekk, BH Strand - European journal of ageing, 2023 - Springer
This study investigates the relationships between subjective age, intrinsic capacity,
functional ability and health among Norwegians aged 60 years and older. The Norwegian …

Measures of attributes of locomotor capacity in older people: a systematic literature review following the COSMIN methodology

G Honvo, S Sabico, N Veronese, O Bruyère… - Age and …, 2023 - academic.oup.com
Background Locomotor capacity (LC) is an important domain of intrinsic capacity and key
determinant of functional ability and well-being in older age. The United Nations Decade of …

Associations between vitality/nutrition and the other domains of intrinsic capacity based on data from the INSPIRE ICOPE-Care Program

L Gaussens, E González-Bautista, M Bonnefoy… - Nutrients, 2023 - mdpi.com
Background: The vitality domain of intrinsic capacity (IC) represents the synthesis of
biological interactions and metabolism. As part of the Integrated Care for Older People …

[HTML][HTML] Association between intrinsic capacity and sarcopenia in hospitalized older patients

L Zhu, X Zong, X Shi, X Ouyang - The Journal of nutrition, health and aging, 2023 - Elsevier
Objectives This study aimed to clarify the association between intrinsic capacity (IC) and
sarcopenia in hospitalized older patients. Design A cross-sectional study. Setting Hospital …

Measurement properties of instruments to measure the fatigue domain of vitality capacity in community-dwelling older people: an umbrella review of systematic …

V Knoop, E Mathot, F Louter, D Beckwee… - Age and …, 2023 - academic.oup.com
Background Vitality capacity (VC) is a key domain of intrinsic capacity (IC) and is the
underlying biophysiological aspect of IC. Energy and metabolism (E&M) is one of the …