Lysosomal storage diseases are usually considered to be pathologies in which the passive
deposition of unwanted materials leads to functional changes in lysosomes. Lysosomal …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of
fatal liver diseases such as cirrhosis, liver cancer, and indications for orthotopic liver …

Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and
oxidative stress, which are important factors contributing to the development of brain …

Spontaneous preterm birth (PTB) and preterm pre-labor rupture of the membranes (pPROM)
are major pregnancy complications. Although PTB and pPROM have common etiologies …

Great efforts have been made in revealing the mechanisms governing cancer resistance
and recurrence. The in-situ effects of cell death, caused by hypoxia and metabolic stress …

Elevated pro-inflammatory biomarkers and cytokines are associated with morbidity and
mortality in heart failure (HF). Preclinical and clinical studies have shown multiple …

High-mobility group box 1 (HMGB1) is one of the most abundant proteins in eukaryotes and
the best characterized damage-associated molecular pattern (DAMP). The biological …

The intestinal tract harbors a diverse community of microbes that have co-evolved with the
host immune system. Although many of these microbes execute functions that are critical for …