Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …

Background: Neonatal seizures are a common neurological emergency in newborns.
Phenobarbital (PB) is the first-line antiepileptic drug (AED). However, PB has some side …

METHODS: The study was a multicenter, randomized, blinded, controlled, phase IIb trial
investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first …

Seizures are common in newborn infants with hypoxic-ischemic encephalopathy and are
highly associated with adverse neurodevelopmental outcomes. The impact of seizure …

Aim The existing treatment options for neonatal seizures have expanded over the last few
decades, but no consensus has been reached regarding the optimal therapeutic protocols …

Background Among autonomic seizures apnea still represent a challenge for physicians,
and it might constitute the only isolated sign of neurological disorder. The aim of this review …

Objectives We aimed to evaluate the use of intravenous levetiracetam as the first-line
treatment of neonatal seizures compared with phenobarbital. Methods The study was …

Background Newborn infants are more prone to seizures than older children and adults. The
neuronal injury caused by seizures in neonates often results in long‐term …

High neonatal seizure burden is associated with worsened neurodevelopmental outcomes.
We compared the efficacy of initial treatment with levetiracetam vs phenobarbital for …

Neonatal seizures are a common neurologic emergency for which therapies have not
significantly changed in decades. Improvements in diagnosis and pathophysiologic …