A beginner's guide to eukaryotic genome annotation
M Yandell, D Ence - Nature Reviews Genetics, 2012 - nature.com
The falling cost of genome sequencing is having a marked impact on the research
community with respect to which genomes are sequenced and how and where they are …
community with respect to which genomes are sequenced and how and where they are …
Coevolution between transposable elements and recombination
One of the most striking patterns of genome structure is the tight, typically negative,
association between transposable elements (TEs) and meiotic recombination rates. While …
association between transposable elements (TEs) and meiotic recombination rates. While …
Heavy metal exposure influences double strand break DNA repair outcomes
ME Morales, RS Derbes, CM Ade, JC Ortego, J Stark… - PloS one, 2016 - journals.plos.org
Heavy metals such as cadmium, arsenic and nickel are classified as carcinogens. Although
the precise mechanism of carcinogenesis is undefined, heavy metal exposure can …
the precise mechanism of carcinogenesis is undefined, heavy metal exposure can …
Structural variants caused by Alu insertions are associated with risks for many human diseases
LM Payer, JP Steranka, WR Yang… - Proceedings of the …, 2017 - National Acad Sciences
Interspersed repeat sequences comprise much of our DNA, although their functional effects
are poorly understood. The most commonly occurring repeat is the Alu short interspersed …
are poorly understood. The most commonly occurring repeat is the Alu short interspersed …
A mobile threat to genome stability: The impact of non-LTR retrotransposons upon the human genome
MK Konkel, MA Batzer - Seminars in cancer biology, 2010 - Elsevier
It is now commonly agreed that the human genome is not the stable entity originally
presumed. Deletions, duplications, inversions, and insertions are common, and contribute …
presumed. Deletions, duplications, inversions, and insertions are common, and contribute …
The fine-scale recombination rate variation and associations with genomic features in a butterfly
Recombination is a key molecular mechanism that has profound implications on both micro-
and macroevolutionary processes. However, the determinants of recombination rate …
and macroevolutionary processes. However, the determinants of recombination rate …
Mobile element scanning (ME-Scan) by targeted high-throughput sequencing
DJ Witherspoon, J Xing, Y Zhang, WS Watkins… - BMC genomics, 2010 - Springer
Abstract Background Mobile elements (MEs) are diverse, common and dynamic inhabitants
of nearly all genomes. ME transposition generates a steady stream of polymorphic genetic …
of nearly all genomes. ME transposition generates a steady stream of polymorphic genetic …
Transposable element insertions have strongly affected human evolution
RJ Britten - Proceedings of the National Academy of …, 2010 - National Acad Sciences
Comparison of a full collection of the transposable element (TE) sequences of vertebrates
with genome sequences shows that the human genome makes 655 perfect full-length …
with genome sequences shows that the human genome makes 655 perfect full-length …
The structural, functional and evolutionary impact of transposable elements in eukaryotes
Transposable elements (TEs) are nearly ubiquitous in eukaryotes. The increase in genomic
data, as well as progress in genome annotation and molecular biology techniques, have …
data, as well as progress in genome annotation and molecular biology techniques, have …
On the sequence‐directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations …
Different types of human gene mutation may vary in size, from structural variants (SVs) to
single base‐pair substitutions, but what they all have in common is that their nature, size and …
single base‐pair substitutions, but what they all have in common is that their nature, size and …