Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome
(aHUS) are acute, rare life‐threatening thrombotic microangiopathies that require rapid …

The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …

Background Hemolytic uremic syndrome (HUS) is a leading cause of acute kidney injury in
children. Although international guidelines emphasize comprehensive evaluation and …

Background Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy
characterized by hemolysis, platelet consumption, and renal injury. Eculizumab, a mAb that …

Objectives: Recent studies have shown that complement hyperactivation contributes to
development of thrombotic microangiopathy. The evaluation of complement biomarkers is …

Complement activation and recruitment of inflammatory leukocytes is an important defense
mechanism against bacterial infection. However, complement also can mediate cellular …

Serum complement cascade, a part of innate immunity required for host protection against
invading pathogens, is also a mediator of various forms of disease and injury. It is activated …

Current technologies for aptamer discovery typically leverage the systematic evolution of
ligands by exponential enrichment (SELEX) concept by recursively panning semi …

Thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome
(aHUS) are thrombotic microangiopathies (TMAs) that can present in pregnancy. The …

The recent discovery of mutations in the gene encoding diacylglycerol kinase ε (DGKE)
identified a novel pathophysiologic mechanism leading to HUS and/or MPGN. We report ten …