Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

Acute Respiratory Distress Syndrome (ARDS) is a clinically severe respiratory disease that
causes severe medical and economic burden. To improve therapeutic efficacy, effectively …

Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …

Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular
matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals …

The interactions between cells and their surrounding extracellular matrix (ECM) are dynamic
and play critical roles in cell migration during development, health, and diseases. Recent …

Radiolabeled fibroblast activation protein (FAP) inhibitors (FAPIs) and Arg-Gly-Asp (RGD)
peptides have been extensively investigated for imaging of FAP-and integrin αvβ3–positive …

The expansion of acute myeloid leukemia (AML) blasts not only suppresses normal
hematopoiesis, but also alters the microenvironment. The interplay of different components …

In the era of precision medicine, liquid biopsy techniques, especially the use of urine
analysis, represent a paradigm shift in the identification of biomarkers, with considerable …

Recent studies have demonstrated that cancer-associated adipocytes (CAAs) in the tumor
microenvironment are involved in the malignant progression of breast cancer. However, the …