The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets

A Adamu, S Li, F Gao, G Xue - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Neuroinflammation refers to a highly complicated reaction of the central nervous system
(CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a …

[HTML][HTML] Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?

PF Høilund-Carlsen, A Alavi, RJ Castellani… - International Journal of …, 2024 - mdpi.com
The amyloid cascade hypothesis for Alzheimer's disease is still alive, although heavily
challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis' claim that …

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

S Nag, O Mitra, G Tripathi, S Samanta… - Immunity …, 2023 - Wiley Online Library
Background Autoimmune diseases (AD) are severe pathophysiological ailments that are
stimulated by an exaggerated immunogenic response towards self‐antigens, which can …

[HTML][HTML] Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents

E Barresi, E Baglini, V Poggetti, J Castagnoli… - Molecules, 2024 - mdpi.com
Neurodegeneration is a gradual decay process leading to the depletion of neurons in both
the central and peripheral nervous systems, ultimately resulting in cognitive dysfunctions …

Unveiling the promise: Exosomes as game‐changers in anti‐infective therapy

VP Chavda, G Luo, R Bezbaruah, T Kalita… - …, 2024 - Wiley Online Library
Extracellular vesicles (EVs)‐based intercellular communication (through exosomes,
microvesicles, and apoptotic bodies) is conserved across all kingdoms of life. In recent …

Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review

JJ Pei, CP Palanisamy, PM Natarajan… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) stands as a formidable challenge in modern medicine,
characterized by progressive neurodegeneration, cognitive decline, and memory …

[HTML][HTML] Hematopoietic Stem Cells and Their Niche in Bone Marrow

M Kwon, BS Kim, S Yoon, SO Oh, D Lee - International Journal of …, 2024 - mdpi.com
Extensive research has explored the functional correlation between stem cells and
progenitor cells, particularly in blood. Hematopoietic stem cells (HSCs) can self-renew and …

[HTML][HTML] Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

HK Choi, M Chen, LL Goldston, KB Lee - Nano Convergence, 2024 - Springer
Abstract Central Nervous System (CNS) disorders represent a profound public health
challenge that affects millions of people around the world. Diseases such as Alzheimer's …

[HTML][HTML] Precision Nanomedicine with Bio-Inspired Nanosystems: Recent Trends and Challenges in Mesenchymal Stem Cells Membrane-Coated Bioengineered …

MS Baig, A Ahmad, RR Pathan, RK Mishra - Journal of Xenobiotics, 2024 - mdpi.com
In the recent past, the formulation and development of nanocarriers has been elaborated
into the broader fields and opened various avenues in their preclinical and clinical …

[HTML][HTML] Neuroimmunomodulatory Properties of Laquinimod

PG Amrutha, S Banoth, J Banothu - Brain Disorders, 2024 - Elsevier
Abstract Laquinimod (ABR-215062) is a quinolone-3-carboxamide derivative, which is an
orally active immunostimulatory drug molecule and is being developed for multiple sclerosis …