Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses

AY Kostygov, A Karnkowska, J Votýpka… - Open …, 2021 - royalsocietypublishing.org
Euglenozoa is a species-rich group of protists, which have extremely diverse lifestyles and a
range of features that distinguish them from other eukaryotes. They are composed of free …

How to master the host immune system? Leishmania parasites have the solutions!

M Rossi, N Fasel - International immunology, 2018 - academic.oup.com
Infection by protozoan parasites of the genus Leishmania results in the development of
leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people …

[HTML][HTML] Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism

C Bogdan - Cytokine: X, 2020 - Elsevier
Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

When do co-infections matter?

AJ McArdle, A Turkova… - Current opinion in …, 2018 - journals.lww.com
When do co-infections matter? : Current Opinion in Infectious Diseases When do co-infections
matter? : Current Opinion in Infectious Diseases Log in or Register Subscribe to journalSubscribe …

Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs

PM Kaye, I Cruz, A Picado, K Van Bocxlaer… - Seminars in …, 2020 - Springer
Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging
to the genus Leishmania. In humans, it has two main clinical forms, visceral leishmaniasis …

Diversity and dissemination of viruses in pathogenic protozoa

S Heeren, I Maes, M Sanders, LF Lye, V Adaui… - Nature …, 2023 - nature.com
Viruses are the most abundant biological entities on Earth and play a significant role in the
evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of …

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

RVH de Carvalho, DS Lima-Junior… - Nature …, 2019 - nature.com
Leishmania RNA virus (LRV) is an important virulence factor associated with the
development of mucocutaneous Leishmaniasis, a severe form of the disease. LRV-mediated …

Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania

D Grybchuk, NS Akopyants… - Proceedings of the …, 2018 - National Acad Sciences
Knowledge of viral diversity is expanding greatly, but many lineages remain underexplored.
We surveyed RNA viruses in 52 cultured monoxenous relatives of the human parasite …

Viruses of protozoan parasites and viral therapy: Is the time now right?

P Barrow, JC Dujardin, N Fasel, AD Greenwood… - Virology journal, 2020 - Springer
Infections caused by protozoan parasites burden the world with huge costs in terms of
human and animal health. Most parasitic diseases caused by protozoans are neglected …

Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis

R Kumar, PT Bunn, SS Singh, SS Ng, MM de Oca… - Cell reports, 2020 - cell.com
Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However,
they also suppress protective immune responses in some infectious diseases. Here, we …