[HTML][HTML] New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

Y Zhu, Z Ouyang, H Du, M Wang, J Wang, H Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach

SN Zarneshan, S Fakhri, H Khan - Pharmacological research, 2022 - Elsevier
Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …

[HTML][HTML] Anti-viral triterpenes: a review

P Darshani, S Sen Sarma, AK Srivastava… - Phytochemistry …, 2022 - Springer
Triterpenes are naturally occurring derivatives biosynthesized following the isoprene rule of
Ruzicka. The triterpenes have been reported to possess a wide range of therapeutic …

Advances in the biosynthesis and metabolic engineering of rare ginsenosides

M Li, M Ma, Z Wu, X Liang, Q Zheng, D Li, T An… - Applied Microbiology …, 2023 - Springer
Rare ginsenosides are the deglycosylated secondary metabolic derivatives of major
ginsenosides, and they are more readily absorbed into the bloodstream and function as …

[HTML][HTML] Ginsenosides from Panax ginseng as Key Modulators of NF-κB Signaling Are Powerful Anti-Inflammatory and Anticancer Agents

WY Jang, JY Hwang, JY Cho - International Journal of Molecular …, 2023 - mdpi.com
Nuclear factor kappa B (NF-κB) signaling pathways progress inflammation and immune cell
differentiation in the host immune response; however, the uncontrollable stimulation of NF …

[HTML][HTML] Ginsenoside and its therapeutic potential for cognitive impairment

H Feng, M Xue, H Deng, S Cheng, Y Hu, C Zhou - Biomolecules, 2022 - mdpi.com
Cognitive impairment (CI) is one of the major clinical features of many neurodegenerative
diseases. It can be aging-related or even appear in non-central nerve system (CNS) …

[HTML][HTML] Engineering considerations to produce bioactive compounds from plant cell suspension culture in bioreactors

EA Motolinía-Alcántara, CO Castillo-Araiza… - Plants, 2021 - mdpi.com
The large-scale production of plant-derived secondary metabolites (PDSM) in bioreactors to
meet the increasing demand for bioactive compounds for the treatment and prevention of …

A novel hybrid scan approach enabling the ion-mobility separation and the alternate data-dependent and data-independent acquisitions (HDDIDDA): Its combination …

H Wang, X Wang, X Xu, Y Hu, X Li, X Shi, S Wang… - Analytica Chimica …, 2022 - Elsevier
Data-dependent acquisition (DDA) and data-independent acquisition (DIA)-based MS n
strategies are extensively applied in metabolites characterization. DDA gives accurate MS n …

[HTML][HTML] Structure-function and engineering of plant UDP-glycosyltransferase

M Wang, Q Ji, B Lai, Y Liu, K Mei - Computational and Structural …, 2023 - Elsevier
Natural products synthesized by plants have substantial industrial and medicinal values and
are therefore attracting increasing interest in various related industries. Among the key …

[HTML][HTML] Terpenoids: Natural compounds for non-alcoholic fatty liver disease (NAFLD) therapy

P Yao, Y Liu - Molecules, 2022 - mdpi.com
Natural products have been the most productive source for the development of drugs.
Terpenoids are a class of natural active products with a wide range of pharmacological …