Therapeutic hypothermia is the only treatment currently recommended for moderate or
severe encephalopathy of hypoxic‒ischaemic origin in term neonates. Though the effects of …

Hypoxic-ischemic encephalopathy (HIE) is a severe central nervous system injury in
neonates secondary to perinatal asphyxia. It may cause devastating lifelong neurocognitive …

Knowledge about the safe and effective use of medicines in neonates has increased
substantially but has resulted in few label changes. Drugs developed for use in adults are …

Neuroprotective controlled therapeutic hypothermia is the standard of care for newborns
suffering perinatal asphyxia. Antibiotic drugs, such as amikacin, gentamicin, and …

Background: Phenobarbital and midazolam are commonly used drugs in (near-) term
neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for …

Introduction: The brain magnetic resonance imaging (MRI) result is a major predictor for the
outcome of term infants with perinatal asphyxia who underwent therapeutic hypothermia. In …

Objectives In the absence of consensus, the present meta-analysis was performed to
determine an optimal dosing regimen of vancomycin for neonates. Methods A 'meta …

Pharmacokinetics and-dynamics show important changes throughout childhood. Studies on
the different maturational processes that influence developmental pharmacology have been …

Introduction: Legal initiatives to stimulate neonatal drug development should be
accompanied by development of valid research tools. Physiologically based (PB) …

Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for
potentially reversible neonatal cardiac and/or respiratory failure. As the survival and the …