The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Admixture mapping is based on the hypothesis that differences in disease rates between
populations are due in part to frequency differences in disease-causing genetic variants. In …

Population mixture is an important process in biology. We present a suite of methods for
learning about population mixtures, implemented in a software package called …

Modern genetic data combined with appropriate statistical methods have the potential to
contribute substantially to our understanding of human history. We have developed an …

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of
genetic variation across the continent remains enigmatic. Here we report a large-scale …

To date, most genome-wide association studies (GWAS) and studies of fine-scale
population structure have been conducted primarily on Europeans. Han Chinese, the largest …

Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …

We present a two-layer hidden Markov model to detect the structure of haplotypes for
unrelated individuals. This allows us to model two scales of linkage disequilibrium (one …

Background Genetic variability in the cytochrome P450 CYP2C9 constitutes an important
predictor for efficacy and safety of various commonly prescribed drugs, including coumarin …

Geographic patterns of genetic variation within modern populations, produced by complex
histories of migration, can be difficult to infer and visually summarize. A general …