Disclosure: Dr MJ Barry is President of the Informed Medical Decisions Foundation, a part of
Healthwise, where he is also Chief Science Officer. Healthwise is a 501 (c) 3 nonprofit …

The link between prostate cancer (PC) development and lipid metabolism is well
established, with AR intimately involved in a number of lipogenic processes involving …

Lethal prostate cancers have higher expression of squalene monooxygenase (SQLE), the
second rate-limiting enzyme of cholesterol synthesis. Preclinical studies suggested that …

Purpose Treating small-cell lung cancer (SCLC) remains a therapeutic challenge.
Experimental studies show that statins exert additive effects with agents, such as cisplatin, to …

The widespread clinical use of statins has contributed to significant reductions of
cardiovascular morbidity and mortality. Increasing preclinical and epidemiological …

Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have
de novo resistance, and all will develop resistance to current therapeutics over time …

Abstract Background and Aim: We have previously shown that high-mobility group box 1
(HMGB1) is an independent biomarker for shortened survival of prostate cancer (PCa) …

Purpose Increasing evidence indicates that statin use may reduce mortality from prostate
cancer. In this work, we examined whether postdiagnosis statin use was associated with …

Lipids are known to influence tumour growth, inflammation and chemoresistance. However,
the association of circulating lipids with the clinical outcome of metastatic castration …

Prostate cancer is the most common type of cancer and the leading cause of cancer deaths
among men in many countries. Preventing progression is a major concern for prostate …