Prevention of prostate cancer morbidity and mortality: primary prevention and early detection
MJ Barry, LH Simmons - Medical Clinics, 2017 - medical.theclinics.com
Disclosure: Dr MJ Barry is President of the Informed Medical Decisions Foundation, a part of
Healthwise, where he is also Chief Science Officer. Healthwise is a 501 (c) 3 nonprofit …
Healthwise, where he is also Chief Science Officer. Healthwise is a 501 (c) 3 nonprofit …
Lipid pathway deregulation in advanced prostate cancer
L Galbraith, HY Leung, I Ahmad - Pharmacological research, 2018 - Elsevier
The link between prostate cancer (PC) development and lipid metabolism is well
established, with AR intimately involved in a number of lipogenic processes involving …
established, with AR intimately involved in a number of lipogenic processes involving …
Cholesterol uptake and regulation in high-grade and lethal prostate cancers
KH Stopsack, TA Gerke, O Andrén… - …, 2017 - academic.oup.com
Lethal prostate cancers have higher expression of squalene monooxygenase (SQLE), the
second rate-limiting enzyme of cholesterol synthesis. Preclinical studies suggested that …
second rate-limiting enzyme of cholesterol synthesis. Preclinical studies suggested that …
Multicenter, phase III, randomized, double-blind, placebo-controlled trial of pravastatin added to first-line standard chemotherapy in small-cell lung cancer …
MJ Seckl, CH Ottensmeier, M Cullen… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Treating small-cell lung cancer (SCLC) remains a therapeutic challenge.
Experimental studies show that statins exert additive effects with agents, such as cisplatin, to …
Experimental studies show that statins exert additive effects with agents, such as cisplatin, to …
[HTML][HTML] New insights into the therapeutic potentials of statins in cancer
C Liu, H Chen, B Hu, J Shi, Y Chen… - Frontiers in …, 2023 - frontiersin.org
The widespread clinical use of statins has contributed to significant reductions of
cardiovascular morbidity and mortality. Increasing preclinical and epidemiological …
cardiovascular morbidity and mortality. Increasing preclinical and epidemiological …
Targeting lipid metabolism in metastatic prostate cancer
T Scheinberg, B Mak, L Butler… - … Advances in Medical …, 2023 - journals.sagepub.com
Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have
de novo resistance, and all will develop resistance to current therapeutics over time …
de novo resistance, and all will develop resistance to current therapeutics over time …
[HTML][HTML] HMGB1 promotes prostate cancer development and metastasis by interacting with Brahma-related gene 1 and activating the Akt signaling pathway
DJ Lv, XL Song, B Huang, YZ Yu, FP Shu, C Wang… - Theranostics, 2019 - ncbi.nlm.nih.gov
Abstract Background and Aim: We have previously shown that high-mobility group box 1
(HMGB1) is an independent biomarker for shortened survival of prostate cancer (PCa) …
(HMGB1) is an independent biomarker for shortened survival of prostate cancer (PCa) …
Postdiagnosis statin use and mortality in Danish patients with prostate cancer
SB Larsen, C Dehlendorff, C Skriver… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Increasing evidence indicates that statin use may reduce mortality from prostate
cancer. In this work, we examined whether postdiagnosis statin use was associated with …
cancer. In this work, we examined whether postdiagnosis statin use was associated with …
A distinct plasma lipid signature associated with poor prognosis in castration‐resistant prostate cancer
Lipids are known to influence tumour growth, inflammation and chemoresistance. However,
the association of circulating lipids with the clinical outcome of metastatic castration …
the association of circulating lipids with the clinical outcome of metastatic castration …
[HTML][HTML] Main inflammatory cells and potentials of anti-inflammatory agents in prostate cancer
T Hayashi, K Fujita, M Matsushita, N Nonomura - Cancers, 2019 - mdpi.com
Prostate cancer is the most common type of cancer and the leading cause of cancer deaths
among men in many countries. Preventing progression is a major concern for prostate …
among men in many countries. Preventing progression is a major concern for prostate …