The cell cycle is the series of events that take place in a cell, which drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the …

The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated
protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells …

The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to
regulate cell growth (increased cell mass and cell size) and cell division. The …

Recent advances in our understanding of both the regulation of components of the
translational machinery and the upstream signalling pathways that modulate them have …

mRNP remodeling events required for the transition of an mRNA from active translation to
degradation are currently poorly understood. We identified protein factors potentially …

Protein synthesis requires both amino acids, as precursors, and a substantial amount of
metabolic energy. It is well established that starvation or lack of nutrients impairs protein …

Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic
acid receptor alpha in acute promyelocytic leukemia patients with the (15; 17) chromosomal …

This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical
node in an RNA regulon that impacts nearly every stage of cell cycle progression …

The eukaryotic translation initiation factor eIF4E is deregulated in many human cancers, and
its overexpression in cells leads to malignant transformation. Oncogenic properties of eIF4E …

Eukaryotic initiation factor 4E (eIF4E) plays an important role in mRNA translation by binding
the 5′‐cap structure of the mRNA and facilitating the recruitment to the mRNA of other …