Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: the special case of molnupiravir

MD Waters, S Warren, C Hughes… - Environmental and …, 2022 - Wiley Online Library
This review considers antiviral nucleoside analog (NA) drugs, including ribavirin, favipiravir,
and molnupiravir, which induce genome error catastrophe in SARS‐CoV or SARS‐CoV‐2 …

Tropism of the chikungunya virus

G Matusali, F Colavita, L Bordi, E Lalle, G Ippolito… - Viruses, 2019 - mdpi.com
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne virus that displays a large cell
and organ tropism, and causes a broad range of clinical symptoms in humans. It is …

Interferon-β-1a inhibition of severe acute respiratory syndrome–coronavirus 2 in vitro when administered after virus infection

N Clementi, R Ferrarese, E Criscuolo… - The Journal of …, 2020 - academic.oup.com
The ongoing coronavirus disease 2019 pandemic has forced the clinical and scientific
community to try drug repurposing of existing antiviral agents as a quick option against …

Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro

B Troost, LM Mulder, M Diosa-Toro, D van de Pol… - Scientific Reports, 2020 - nature.com
In recent decades, chikungunya virus (CHIKV) has re-emerged, leading to outbreaks of
chikungunya fever in Africa, Asia and Central and South America. The disease is …

Antivirals against the Chikungunya virus

V Battisti, E Urban, T Langer - Viruses, 2021 - mdpi.com
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in
recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection …

Overview on chikungunya virus infection: from epidemiology to state-of-the-art experimental models

LEC Constant, BF Rajsfus, PH Carneiro… - Frontiers in …, 2021 - frontiersin.org
Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public
health. It is a member of the Togaviridae family and alphavirus genus and causes an …

Antiviral drug delivery system for enhanced bioactivity, better metabolism and pharmacokinetic characteristics

R Chen, T Wang, J Song, D Pu, D He, J Li… - International journal …, 2021 - Taylor & Francis
Antiviral drugs (AvDs) are the primary resource in the global battle against viruses, including
the recent fight against corona virus disease 2019 (COVID-19). Most AvDs require multiple …

Current and promising antivirals against chikungunya virus

FIL Hucke, JJ Bugert - Frontiers in Public Health, 2020 - frontiersin.org
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever (CHIKF) and is
categorized as a (n)(re) emerging arbovirus. CHIKV has repeatedly been responsible for …

[6]‐Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication

RF Hayati, CD Better, D Denis… - BioMed research …, 2021 - Wiley Online Library
Chikungunya (CHIK) is a reemerging arboviral disease caused by chikungunya virus
(CHIKV) infection. The disease is clinically hallmarked by prolonged debilitating joint pain …

Small-molecule inhibitors of chikungunya virus: mechanisms of action and antiviral drug resistance

K Kovacikova, MJ van Hemert - Antimicrobial Agents and …, 2020 - Am Soc Microbiol
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has spread to more
than 60 countries worldwide. CHIKV infection leads to a febrile illness known as …