In patients with heart failure (HF), the neuroendocrine systems of the sympathetic nervous
system (SNS), the renin–angiotensin–aldosterone system (RAAS) and the arginine …

Heart failure (HF) is a major public health problem worldwide, especially coronary heart
disease (myocardial infarction)-induced HF with reduced ejection fraction (HFrEF), which …

Neurotransmitter release from sympathetic terminals is a key avenue for heart regulation.
Herein, presynaptic exocytotic activity was monitored in mice atrial tissue using a false …

Overnight increases in arterial stiffness associated with sleep-disordered breathing may
adversely affect patients with acute heart failure. Thus, we investigated overnight changes in …

Aims Physical symptoms impact patients with heart failure (HF) despite treatment
advancements; however, our understanding of the pathogenic mechanisms underlying HF …

Hyponatremia is the most common electrolyte disorder in clinical practice, which may lead to
life-threatening complications. Several lines of evidence suggest that hyponatremia is …

Despite advancements in treatments for heart failure and lethal arrhythmias, achieving
satisfactory life prognoses remains a challenge. A fresh perspective on the pathogenesis of …

Background Sympathoexcitation contributes to myocardial remodeling in heart failure (HF).
Increased circulating pro-inflammatory mediators directly act on the Subfornical organ …

High levels of oxidant stress in the form of reactive oxidant species (ROS) are prevalent in
the circulation and tissues in various types of cardiovascular disease including heart failure …

Introduction Hyperinsulinemia and hyperglycemia are associated with exaggerated systemic
sympathetic nerve activity (SNA) in patients with type 2 diabetes. Sodium–glucose …