When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to
play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique …

Hepatitis C virus (HCV) is a global public health problem involving chronic infection of the
liver, which can cause liver disease and is linked with liver cancer. Viral innate immune …

Five human hepatitis viruses cause most of the acute and chronic liver disease worldwide.
Over the past 25 years, hepatitis C virus (HCV) in particular has received much interest …

Epithelial cells are a major port of entry for many viruses, but the molecular networks which
protect barrier surfaces against viral infections are incompletely understood. Viral infections …

Background & Aims Most viruses are detected at early stages of cell infection and induce an
innate immune response mediated by production of interferons (IFNs). IFNs induce …

Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …