Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

Choroidal neovascularization (CNV) is an important characteristic of advanced wet age‐
related macular degeneration (AMD) and leads to severe visual impairment among elderly …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Vesicular structures called microvesicles (MVs) that are shed from the surfaces of cancer
cells are capable of transferring oncogenic cargo to recipient cancer cells, as well as to …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

Background: As new biomarkers of coronary artery diseases (CAD) emerge via
metabolomics, the underlying functional mechanisms remain to be elucidated. Functional …

During the development of the pulmonary vasculature in the fetus, many structural and
functional changes occur to prepare the lung for the transition to air breathing. The …