A marked decrease in human cancers, including breast cancer, bone cancer, and cervical
cancer, has been linked to the consumption of vegetable and fruit, and the corresponding …

ABSTRACT “Let food be thy medicine and medicine be thy food” was expressed by
Hippocrates more than 2000 years ago and the health benefits of natural food products have …

Kaempferol (kae) and its glycosides are widely distributed in nature and show multiple
bioactivities, yet few reports have compared them. In this paper, we report the antitumor …

Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective
effect on human health. Identifying bioactive dietary constituents is an active area of …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

The high failure rate of the reductionist approach to discover effective and safe drugs to treat
chronic inflammatory diseases has led scientists to seek alternative ways. Recently …

Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including
transcription factors thereby regulating metabolism, stress resistance, cellular survival …

A member of the sirtuin family of NAD+-dependent deacetylases, SIRT3, is identified as one
of the major mitochondrial deacetylases located in mammalian mitochondria responsible for …

Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been
widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show …