Mechanisms of early placental development in mouse and humans
The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …
Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
Sculpting the transcriptome during the oocyte-to-embryo transition in mouse
In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …
Environmentally induced epigenetic toxicity: potential public health concerns
EL Marczylo, MN Jacobs, TW Gant - Critical reviews in toxicology, 2016 - Taylor & Francis
Throughout our lives, epigenetic processes shape our development and enable us to adapt
to a constantly changing environment. Identifying and understanding environmentally …
to a constantly changing environment. Identifying and understanding environmentally …
Control of LINE-1 expression maintains genome integrity in germline and early embryo development
Maintenance of genome integrity in the germline and in preimplantation embryos is crucial
for mammalian development. Epigenetic remodeling during primordial germ cell (PGC) and …
for mammalian development. Epigenetic remodeling during primordial germ cell (PGC) and …
[HTML][HTML] The Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy
Transcriptional regulation and epigenetic mechanisms closely control gene expression
through diverse physiological and pathophysiological processes. These include the …
through diverse physiological and pathophysiological processes. These include the …
Evolutionary history of DNA methylation related genes in chordates: new insights from multiple whole genome duplications
DNA methylation is an important epigenetic mechanism involved in many biological
processes, ie gametogenesis and embryonic development. However, increased copy …
processes, ie gametogenesis and embryonic development. However, increased copy …
Pathomechanisms of prenatally programmed adult diseases
Based on epidemiological observations Barker et al. put forward the hypothesis/concept that
an adverse intrauterine environment (involving an insufficient nutrient supply, chronic …
an adverse intrauterine environment (involving an insufficient nutrient supply, chronic …
Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal-and plant-based high-fat diets
CC Fontelles, LN Guido, MP Rosim, FO Andrade… - Breast Cancer …, 2016 - Springer
Background Although males contribute half of the embryo's genome, only recently has
interest begun to be directed toward the potential impact of paternal experiences on the …
interest begun to be directed toward the potential impact of paternal experiences on the …
[HTML][HTML] Epigenetics: A key paradigm in reproductive health
N Bunkar, N Pathak, NK Lohiya… - Clinical and Experimental …, 2016 - ncbi.nlm.nih.gov
It is well established that there is a heritable element of susceptibility to chronic human
ailments, yet there is compelling evidence that some components of such heritability are …
ailments, yet there is compelling evidence that some components of such heritability are …