Inflammation has been implicated in the initiation and progression of gastrointestinal (GI)
cancers. Inflammation also plays important roles in subverting immune tolerance, escape …

Flavonoids have the potential to modulate inflammation by inhibition of cyclooxygenase-2
(COX-2) transcription. In this study, we compared the effect of the human flavonoid plasma …

In the human colon, arachidonic acid is metabolized primarily by cyclooxygenase (COX) and
arachidonate lipoxygenase (ALOX) to bioactive lipids, which are implicated in colon cancer …

Radiation therapy continues to be one of the more popular treatment options for localized
prostate cancer. One major obstacle to radiation therapy is that there is a limit to the amount …

AIM: To explore the activation of signal transduction pathways related with the
carcinogenesis of sporadic colon cancers. METHODS: A gene array monitoring the …

In recent years, the design of new antineoplastic agents that can halt the progression of
human malignancies with minimal systemic damage has been at the forefront of cancer …

Mitogen-activated protein kinase (MAPK) pathways transduce signals from a diverse array of
extracellular stimuli. The three primary MAPK-signaling pathways are the extracellular …

Abstract Cyclooxygenase-2 (COX-2) has been identified as a potential target for prevention
and therapy of human colorectal cancers (CRC) and other cancers. Because right-sided …

Background: Because of clinicopathologic and genetic differences between left-sided
colorectal cancer (LSCRC) and right-sided colon cancer (RSCC), cyclooxygenase-2 (COX …

BACKGROUND. Lipoxygenases (LOX) are major enzymes that metabolize arachidonic acid
to hydroxyl‐eicosatetraenoic acids and leukotrienes, which have been implicated in …