The therapeutic potential of the anticancer activity of fucoidan: Current advances and hurdles

JO Jin, PS Chauhan, AP Arukha, V Chavda, A Dubey… - Marine Drugs, 2021 - mdpi.com
Several types of cancers share cellular and molecular behaviors. Although many
chemotherapy drugs have been designed to weaken the defenses of cancer cells, these …

Neonatal and juvenile exposure to perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS): advance puberty onset and kisspeptin system disturbance in …

G Du, J Hu, Z Huang, M Yu, C Lu, X Wang… - … and environmental safety, 2019 - Elsevier
Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are widespread and
persistent chemicals in the environment, and limited data about their effects on puberty …

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

C Gonçalves, D Fernandes, I Silva, V Mateus - Molecules, 2022 - mdpi.com
This systematic review aimed to evaluate the potential anti-inflammatory effect of
Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted …

Effect of fluoride on major organs with the different time of exposure in rats

T Perera, S Ranasinghe, N Alles, R Waduge - Environmental health and …, 2018 - Springer
Background High fluoride levels in drinking water in relation to the prevalence of chronic
kidney disease of unknown etiology (CKDu) in Sri Lanka were investigated using rats as an …

Methods for in vivo studies in rodents of chemotherapy induced peripheral neuropathy

J Bruna, P Alberti, A Calls-Cobos, M Caillaud… - Experimental …, 2020 - Elsevier
Peripheral neuropathy is one of the most common, dose limiting, and long-lasting disabling
adverse events of chemotherapy treatment. Unfortunately, no treatment has proven efficacy …

American ginseng with different processing methods ameliorate immunosuppression induced by cyclophosphamide in mice via the MAPK signaling pathways

YT Zhang, W Tian, YS Lu, ZM Li, DD Ren… - Frontiers in …, 2023 - frontiersin.org
This study aimed to clarify the effects of two processed forms of American ginseng (Panax
quinquefolius L.) on immunosuppression caused by cyclophosphamide (CTX) in mice. In the …

[HTML][HTML] Metabolic transformation of environmentally-relevant brominated flame retardants in Fauna: A review

TA Smythe, G Su, Å Bergman, RJ Letcher - Environment international, 2022 - Elsevier
Over the past few decades, production trends of the flame retardant (FR) industry, and
specifically for brominated FRs (BFRs), is for the replacement of banned and regulated …

The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species

J Basso, KJ Chen, Y Zhou, L Mark, D LaSala… - Frontiers in …, 2023 - frontiersin.org
Brensocatib is a novel, oral, selective, reversible inhibitor of dipeptidyl peptidase 1 (DPP1),
which activates several neutrophil serine proteases (NSPs), including neutrophil elastase …

Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism

M Albadry, S Höpfl, N Ehteshamzad, M König… - Scientific reports, 2022 - nature.com
Little is known about the impact of morphological disorders in distinct zones on metabolic
zonation. It was described recently that periportal fibrosis did affect the expression of CYP …

Adiponectin deficiency induces hepatic steatosis during pregnancy and gestational diabetes in mice

BL Moyce Gruber, LK Cole, B Xiang, MA Fonseca… - Diabetologia, 2022 - Springer
Aims/hypothesis Obesity and hepatic steatosis are risk factors for gestational diabetes
mellitus (GDM), a common complication of pregnancy. Adiponectin is a fat-derived hormone …