PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …

The discovery of synthetic lethality as a result of the combined loss of PARP1 and BRCA has
revolutionized the treatment of DNA repair-deficient cancers. With the development of PARP …

The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly
distinct functions–homologous recombination, replication fork protection, and single …

AlphaFold2 and related computational tools have greatly aided studies of structural biology
through their ability to accurately predict protein structures. In the present work, we explored …

Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA
replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress …

Inactivating mutations in the BRCA1 and BRCA2 genes impair DNA double-strand break
(DSB) repair by homologous recombination (HR), leading to chromosomal instability and …

DNA replication stress-induced fork arrest represents a significant threat to genomic
integrity. One major mechanism of replication restart involves repriming downstream of the …

PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with
relevance to cancer, inflammation, and infection. Inhibition of its mono-ADP-ribosylating …

We have previously identified TopBP1 (topoisomerase IIβ-binding protein 1) as a promising
target for cancer therapy, given its role in the convergence of Rb, PI (3) K/Akt, and p53 …

Nonhomologous end-joining (NHEJ) factors act in replication-fork protection, restart, and
repair. Here, we identified a mechanism related to RNA: DNA hybrids to establish the NHEJ …