Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …

Since ketamine was approved by the FDA as an intravenous anesthetic, it has been in
clinical use for more than 50 years. Apart from its anesthetic effects, ketamine is one of the …

Pain and itch are two closely related but essentially distinct sensations that elicit different
behavioral responses. However, it remains mysterious how pain and itch information is …

Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …

Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide
health problem that affects the quality of life of patients and imposes a tremendous …

Negative pain expectation including pain catastrophizing is a well-known clinical
phenomenon whereby patients amplify the aversive value of a painful or oftentimes even a …

The perception of pain is a multidimensional sensory and emotional/affective experience
arising from distributed brain activity. However, the involved brain regions are not specific for …

While dysfunction of the medial prefrontal cortex (mPFC) has been implicated in chronic
pain, the underlying neural circuits and the contribution of specific cellular populations …

Pain is a dynamic, complex and multidimensional experience. The identification of pain from
brain activity as neural readout may effectively provide a neural code for pain, and further …

Chronic pain is a significant global socioeconomic burden with limited long-term treatment
options. The intractable nature of chronic pain stems from two primary factors: the …