Rationale Heart failure is a multimodal disorder, of which disrupted Ca 2+ homeostasis is a
hallmark. Central to Ca 2+ homeostasis is the major cardiac Ca 2+ release channel–the …

Vascular remodeling and endothelial dysfunction are important pathogenic features of
pulmonary arterial hypertension (PAH). There is a growing body of evidence that …

The proteasome inhibitor (PI), bortezomib (Btz), is effective in treating multiple myeloma and
mantle cell lymphoma, but not solid tumors. In this study, we show for the first time that …

Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-
reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network …

Background Haemorrhagic shock after traumatic injury carries a high mortality. Therapeutic
hypothermia has been widely used in critical illness to improve the outcome in …

Halogens are widely used, highly toxic chemicals that pose a potential threat to humans
because of their abundance. Halogens such as bromine (Br2) cause severe pulmonary and …

Cardiac arrhythmogenesis is regulated by channel proteins whose protein levels are in turn
regulated by the ubiquitin–proteasome system (UPS). We have previously reported on UPS …

We tested whether the activation of proteolytic enzymes, calpain, and matrix
metalloproteinases (MMPs) during ischemia–reperfusion (I/R) is mediated through oxidative …

Various procedures such as angioplasty, thrombolytic therapy, coronary bypass surgery,
and cardiac transplantation are invariably associated with ischemia–reperfusion (I/R) injury …

Although irreversible cardiomyocyte injury provokes intracellular Ca2+ ([Ca2+] i) overload,
the underlying dynamics of this response and its effects on cellular morphology remain …