Cardiac fibrosis is a pathological condition that occurs after injury and during aging.
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …

Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …

Loss of physiological microglial function may increase the propagation of
neurodegenerative diseases. Cellular senescence is a hallmark of aging; thus, we …

The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However,
this is a disguise that conceals a highly active metabolic cell state with diverse functionality …

Cellular senescence is a stress response that accompanies stable exit from the cell cycle.
Classically, senescence, particularly in human cells, involves the p53 and p16/Rb pathways …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

Aging is a complex biological process accompanied by a state of chronic, low-grade,'sterile'
inflammation, which is a major contributor to the development of many age-related chronic …

Patients with breast cancer often develop malignant regrowth of residual drug-resistant
dormant tumor cells years after primary treatment, a process defined as cancer relapse …

Most molecular hallmarks of cellular senescence have been identified in studies of cells
aged in vitro by driving them into replicative or stress-induced senescence. Comparatively …