Probing structural basis for enhanced binding of SARS‐CoV‐2 P. 1 variant spike protein with the human ACE2 receptor
The initial step of infection by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐
2) involves the binding of receptor binding domain (RBD) of the spike protein to the …
2) involves the binding of receptor binding domain (RBD) of the spike protein to the …
Investigating REV-ERBβ Binding Pocket Dynamics with Implications for Rational Design of Small Molecule Modulators
S Srivastava, R Thakur, AM Vishnu, A Srivastava - bioRxiv, 2024 - biorxiv.org
REV-ERBβ is a nuclear receptor (NR) with heme as an endogenous ligand that regulates its
transcriptional activity. With key role in cellular functions such as glucose metabolism …
transcriptional activity. With key role in cellular functions such as glucose metabolism …
Nucleoside reverse transcriptase inhibitors are the major class of HIV antiretroviral therapeutics that induce neuropathic pain in mice
K Bush, Y Wairkar, SJ Tang - bioRxiv, 2022 - biorxiv.org
The development of combination antiretroviral therapy (cART) has transformed human
immunodeficiency virus (HIV) infection from a lethal diagnosis into a chronic disease, and …
immunodeficiency virus (HIV) infection from a lethal diagnosis into a chronic disease, and …
Network approach to understand biological systems: From single to multilayer networks
S Chaudhuri, A Srivastava - Journal of Biosciences, 2022 - Springer
Network theory has led to the abstraction of many real-world systems and enabled their
modelling as simple networks comprising nodes and edges. In particular, in the field of …
modelling as simple networks comprising nodes and edges. In particular, in the field of …
Investigating Mechanisms of Nucleoside Reverse Transcriptase Inhibitor Induced Sensory Neuropathy
KM Bush - 2021 - utmb-ir.tdl.org
The success of antiretroviral therapy (ART) has generally improved the survival of HIV-
infected patients. However, patients on ART whose HIV disease is well controlled show …
infected patients. However, patients on ART whose HIV disease is well controlled show …