[HTML][HTML] Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

[HTML][HTML] Significance of interleukin (IL)-4 and IL-13 in inflammatory arthritis

M Iwaszko, S Biały, K Bogunia-Kubik - Cells, 2021 - mdpi.com
Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-
5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important …

Poor translatability of biomedical research using animals—A narrative review

LJ Marshall, J Bailey, M Cassotta… - Alternatives to …, 2023 - journals.sagepub.com
The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …

[HTML][HTML] Mesenchymal stem cell-based therapy for rheumatoid arthritis

M Sarsenova, A Issabekova, S Abisheva… - International journal of …, 2021 - mdpi.com
Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of
cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to …

Cell-based therapies for rheumatoid arthritis: opportunities and challenges

YJ Li, Z Chen - Therapeutic advances in musculoskeletal …, 2022 - journals.sagepub.com
Rheumatoid arthritis (RA) is the most common immune-mediated inflammatory disease
characterized by chronic synovitis that hardly resolves spontaneously. The current treatment …

[HTML][HTML] Xinfeng capsule inhibits inflammation and oxidative stress in rheumatoid arthritis by up-regulating LINC00638 and activating Nrf2/HO-1 pathway

Y Sun, J Liu, L Xin, J Wen, Q Zhou, X Chen… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Xinfeng capsule is a traditional Chinese medicine
compound, which has been clinically used for more than 20 years in the treatment of …

[HTML][HTML] Adipose-derived stem cell exosomes as a novel anti-inflammatory agent and the current therapeutic targets for rheumatoid arthritis

TH Chang, CS Wu, SH Chiou, CH Chang, HJ Liao - Biomedicines, 2022 - mdpi.com
Patients with rheumatoid arthritis (RA), a chronic inflammatory joint disorder, may not
respond adequately to current RA treatments. Mesenchymal stem cells (MSCs) elicit several …

[HTML][HTML] Mesenchymal stem/stromal cell-based therapy for the treatment of rheumatoid arthritis: An update on preclinical studies

M Lopez-Santalla, JA Bueren, MI Garin - EBioMedicine, 2021 - thelancet.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by
synovial inflammation and progressive joint destruction and is a primary cause of disability …

Umbilical cord mesenchymal stem cell therapy for regenerative treatment of rheumatoid arthritis: opportunities and challenges

X Lv, L Wang, XR Zou, S Huang - Drug design, development and …, 2021 - Taylor & Francis
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology with a high rate of
disability. Traditional treatments for RA remain a challenging issue. For example …

[HTML][HTML] Traditional Tibetan medicine twenty-five wei'er tea pills ameliorate rheumatoid arthritis based on chemical crosstalk between gut microbiota and the host

Z Li, L Nie, Y Li, L Yang, L Jin, B Du, J Yang… - Frontiers in …, 2022 - frontiersin.org
Twenty-Five Wei'er Tea Pills (TFP), a traditional Tibetan medicine, has shown to have a
promising therapeutic effect in patients with Rheumatoid arthritis (RA), as well as being safe …