Toward low-cost biological and hybrid biological/catalytic conversion of cellulosic biomass to fuels

LR Lynd, GT Beckham, AM Guss… - Energy & …, 2022 - pubs.rsc.org
Developing economically viable, scalable, and sustainable technologies for the conversion
of lignocellulosic polysaccharides to liquid fuels is widely seen as a centerpiece of the …

Common principles and best practices for engineering microbiomes

CE Lawson, WR Harcombe, R Hatzenpichler… - Nature Reviews …, 2019 - nature.com
Despite broad scientific interest in harnessing the power of Earth's microbiomes, knowledge
gaps hinder their efficient use for addressing urgent societal and environmental challenges …

Synthetic biology tools to engineer microbial communities for biotechnology

NS McCarty, R Ledesma-Amaro - Trends in biotechnology, 2019 - cell.com
Microbial consortia have been used in biotechnology processes, including fermentation,
waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly …

Metabolic engineering of Escherichia coli for natural product biosynthesis

D Yang, SY Park, YS Park, H Eun, SY Lee - Trends in Biotechnology, 2020 - cell.com
Natural products are widely employed in our daily lives as food additives, pharmaceuticals,
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …

Biotechnological basis of microbial consortia for the removal of pesticides from the environment

P Bhatt, K Bhatt, A Sharma, W Zhang… - Critical Reviews in …, 2021 - Taylor & Francis
The application of microbial strains as axenic cultures has frequently been employed in a
diverse range of sectors. In the natural environment, microbes exist as multispecies and …

Escherichia coli as a host for metabolic engineering

S Pontrelli, TY Chiu, EI Lan, FYH Chen, P Chang… - Metabolic …, 2018 - Elsevier
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Engineering microbial division of labor for plastic upcycling

T Bao, Y Qian, Y Xin, JJ Collins, T Lu - Nature communications, 2023 - nature.com
Plastic pollution is rapidly increasing worldwide, causing adverse impacts on the
environment, wildlife and human health. One tempting solution to this crisis is upcycling …

Metabolic burden: cornerstones in synthetic biology and metabolic engineering applications

G Wu, Q Yan, JA Jones, YJ Tang, SS Fong… - Trends in …, 2016 - cell.com
Engineering cell metabolism for bioproduction not only consumes building blocks and
energy molecules (eg, ATP) but also triggers energetic inefficiency inside the cell. The …

Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol

C Yang, Y Wang, Z Su, L Xiong, P Wang, W Lei… - Nature …, 2024 - nature.com
Taxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively
replicating cells. Although a minimum 19-step biosynthetic pathway has been proposed and …

Designing microbial consortia with defined social interactions

W Kong, DR Meldgin, JJ Collins, T Lu - Nature chemical biology, 2018 - nature.com
Designer microbial consortia are an emerging frontier in synthetic biology that enable
versatile microbiome engineering. However, the utilization of such consortia is hindered by …