Non-enzymatic antioxidants against Alzheimer's disease: prevention, diagnosis and therapy
A Varesi, LIM Campagnoli, A Carrara, I Pola, E Floris… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss and cognitive decline. Although substantial research has been conducted to …
memory loss and cognitive decline. Although substantial research has been conducted to …
The multiple sclerosis modulatory potential of natural multi-targeting antioxidants
P Theodosis-Nobelos, EA Rekka - Molecules, 2022 - mdpi.com
Multiple sclerosis (MS) is a complex neurodegenerative disease. Although its pathogenesis
is rather vague in some aspects, it is well known to be an inflammatory process …
is rather vague in some aspects, it is well known to be an inflammatory process …
Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile
GF Makhaeva, NV Kovaleva, NP Boltneva… - Molecules, 2022 - mdpi.com
Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and
reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined …
reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined …
Design, Synthesis, In Silico Studies and In Vitro Evaluation of New Indole-and/or Donepezil-like Hybrids as Multitarget-Directed Agents for Alzheimer's Disease
Alzheimer's disease (AD) is considered a complex neurodegenerative condition which
warrants the development of multitargeted drugs to tackle the key pathogenetic mechanisms …
warrants the development of multitargeted drugs to tackle the key pathogenetic mechanisms …
Preclinical evaluation of novel PET probes for dementia
R Cools, K Kerkhofs, RCF Leitao, G Bormans - Seminars in Nuclear …, 2023 - Elsevier
The development of novel PET imaging agents that selectively bind specific dementia-
related targets can contribute significantly to accurate, differential and early diagnosis of …
related targets can contribute significantly to accurate, differential and early diagnosis of …
Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study
G Papagiouvannis, P Theodosis-Nobelos, EA Rekka - Molecules, 2022 - mdpi.com
Alzheimer's Disease (AD) is a common neurodegenerative disorder characterized by
memory loss and cognitive impairment. Its pathology has not been fully clarified and …
memory loss and cognitive impairment. Its pathology has not been fully clarified and …
Efforts Towards Repurposing of Antioxidant Drugs and Active Compounds for Multiple Sclerosis Control
P Theodosis-Nobelos, EA Rekka - Neurochemical Research, 2023 - Springer
Multiple Sclerosis (MS) is a degenerative disorder of the central nervous system (CNS) with
complicated etiology that has not been clearly analyzed until nowadays. Apart from anti …
complicated etiology that has not been clearly analyzed until nowadays. Apart from anti …
Potential of Tryptamine Derivatives as Multi-Target Directed Ligands for Alzheimer's Disease: AChE, MAO-B, and COX-2 as Molecular Targets
Extensive research has been dedicated to develop compounds that can target multiple
aspects of Alzheimer's disease (AD) treatment due to a growing understanding of AD's …
aspects of Alzheimer's disease (AD) treatment due to a growing understanding of AD's …