Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

Background: Increasing evidence suggests that cardiac arrhythmias are frequent clinical
features of coronavirus disease 2019 (COVID-19). Sinus node damage may lead to …

Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …

The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-
cell RNA sequencing (scRNA-seq) has enabled the profiling of single-cell transcriptomes at …

The heterogeneity of functional cardiomyocytes arises during heart development, which is
essential to the complex and highly coordinated cardiac physiological function. Yet the …

One of the significant limitations of aquaculture worldwide is the prevalence of divalent
copper (Cu). Crayfish (Procambarus clarkii) are economically important freshwater species …

Current transcriptomics technologies, including bulk RNA-seq, single-cell RNA sequencing
(scRNA-seq), single-nucleus RNA-sequencing (snRNA-seq), and spatial transcriptomics …

Although, for many decades, the day–night rhythm in resting heart rate has been attributed
to the parasympathetic branch of the autonomic nervous system (high vagal tone during …