Most patients diagnosed with chronic obstructive pulmonary disease (COPD) present with
hallmark features of airway mucus hypersecretion, including cough and expectoration …

Prolonging duration of action of inhaled drugs is a challenging endeavor and guidance for
medicinal chemistry teams is very limited, particularly if the site of action is intracellular …

A concise review covering updated presence and role of 2-phenethylamines in medicinal
chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are …

Inhaled bronchodilators, including long-acting muscarinic receptor antagonists (LAMA) and
long-acting β2-adrenoreceptor agonists (LABA), are the mainstay of pharmacological …

Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases
including asthma and chronic obstructive pulmonary disease (COPD). However, it has been …

Chronic obstructive pulmonary disease (COPD) remains a leading cause of death
worldwide, yet only one new drug class has been approved in the last decade. However …

Highlights•Several phenotypes characterize chronic obstructive pulmonary disease
(COPD).•Response to pharmacological treatment in COPD is highly variable.•Guidelines …

Introduction Drugs delivered via the lungs are predominantly used to treat various
respiratory disorders, including asthma, chronic obstructive pulmonary diseases, respiratory …

Background: It has been suggested that exhaled breath contains relevant information on
health status. Objectives: We hypothesized that a novel mass spectrometry (MS) technique …

Ozone-induced systemic effects are modulated through activation of the neuro-hormonal
stress response pathway. Adrenal demedullation (DEMED) or bilateral total adrenalectomy …