Cutaneous lupus erythematosus (CLE) is a common disease that may appear as a separate
entity from systemic lupus erythematosus (SLE), precede SLE development, or occur as a …

The current concepts for development of autoreactive B cells in SLE (systemic lupus
erythematosus) focus on extrinsic stimuli and factors that provoke B cells into tolerance loss …

Objectives To elucidate the mechanism of action of baricitinib, a Janus kinase (JAK) 1/2
inhibitor, and describe immunological pathways related to disease activity in adults with …

Background Dedicator of cytokinesis 8 (DOCK8) deficiency is typified by recurrent infections,
increased serum IgE levels, eosinophilia, and a high incidence of allergic and autoimmune …

Tissue-specific immune responses play an important role in the pathology of autoimmune
diseases. In systemic lupus erythematosus, deposits of IgG-immune complexes and the …

Belimumab has therapeutic benefit in active systemic lupus erythematosus (SLE), especially
in patients with high-titer anti-dsDNA antibodies. We asked whether the profound B cell loss …

As our understanding of the pathogenesis of autoimmune diseases is growing, new
therapies are being developed to target disease-specific pathways. Since the introduction of …

Broadly neutralizing antibodies (bNAbs) specific for conserved epitopes on the HIV-1
envelope (Env) are believed to be essential for protection against multiple HIV-1 clades …

B cells are central pathogenic players in systemic lupus erythematosus and multiple other
autoimmune diseases through antibody production as well as antibody independent …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve
several organs. The disease is characterized by a recurring pattern of remission and flare …