The emerging role of Hippo signaling in neurodegeneration
Neurodegeneration refers to the complex process of progressive degeneration or neuronal
apoptosis leading to a set of incurable and debilitating conditions. Physiologically, apoptosis …
apoptosis leading to a set of incurable and debilitating conditions. Physiologically, apoptosis …
The Hippo pathway in colorectal cancer
PM Wierzbicki, A Rybarczyk - Folia histochemica et …, 2015 - journals.viamedica.pl
Colorectal cancer (CRC) is one the most frequently diagnosed neoplastic diseases
worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with …
worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with …
Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice
JH Mao, SA Langley, Y Huang, M Hang… - Scientific reports, 2015 - nature.com
Evidence has emerged that suggests a link between motor deficits, obesity and many
neurological disorders. However, the contributing genetic risk factors are poorly understood …
neurological disorders. However, the contributing genetic risk factors are poorly understood …
KIBRA: In the brain and beyond
L Zhang, S Yang, DO Wennmann, Y Chen… - Cellular signalling, 2014 - Elsevier
In mammals, the KIBRA locus has been associated with memory performance and cognition
by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila …
by genome-wide single nucleotide polymorphism screening. Genetic studies in Drosophila …
[HTML][HTML] Association of HLA-DRB1 polymorphism with Alzheimer's disease: a replication and meta-analysis
RC Lu, W Yang, L Tan, FR Sun, MS Tan, W Zhang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Genome-wide association studies (GWAS) have identified one single-nucleotide
polymorphism (SNP) rs9271192 within HLA-DRB1 as a risk factor for Alzheimer's disease …
polymorphism (SNP) rs9271192 within HLA-DRB1 as a risk factor for Alzheimer's disease …
Impact of KIBRA polymorphism on memory function and the hippocampus in older adults
The single nucleotide polymorphism rs17070145 within the KIBRA gene (kidney and brain
expressed protein) has been associated with variations in memory functions and related …
expressed protein) has been associated with variations in memory functions and related …
Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer's disease
D Chen, W Yu, L Aitken, F Gunn-Moore - Cells, 2021 - mdpi.com
The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream
regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton …
regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton …
Whole transcriptome profiling of the human hippocampus suggests an involvement of the KIBRA rs17070145 polymorphism in differential activation of the MAPK …
IS Piras, J Krate, I Schrauwen, JJ Corneveaux… - …, 2017 - Wiley Online Library
The rs17070145‐T variant of the WWC1 gene, coding for the KIBRA protein, has been
associated with both increased episodic memory performance and lowered risk for late …
associated with both increased episodic memory performance and lowered risk for late …
Untangling huge literature to disinter genetic underpinnings of Alzheimer's disease: A systematic review and meta-analysis
Drug discovery for Alzheimer's Disease (AD) is channeled towards unravelling key disease
specific drug targets/genes to predict promising therapeutic candidates. Though enormous …
specific drug targets/genes to predict promising therapeutic candidates. Though enormous …
KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive …
S Mazzeo, V Bessi, S Padiglioni, S Bagnoli… - Neurological …, 2019 - Springer
KIBRA is a signal transducer protein, mainly expressed in the kidney and brain. A single-
nucleotide polymorphism (SNP rs17070145, T→ C exchange) has been linked to different …
nucleotide polymorphism (SNP rs17070145, T→ C exchange) has been linked to different …