The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Glaucoma, an age-related neurodegenerative disease, is characterized by the death of
retinal ganglion cells (RGCs) and the corresponding loss of visual fields. This disease is the …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the aggregation
of misfolded α-synuclein and progressive spreading of the aggregates from a few discrete …

Iron, as the most abundant metallic element within the human organism, is an indispensable
ion for sustaining life and assumes a pivotal role in governing glucose and lipid metabolism …

Purpose: Glaucoma is a complex degenerative optic neuropathy characterized by loss of
retinal ganglion cells (RGCs) leading to irreversible vision loss and blindness. Solanum …

Endoplasmic reticulum (ER) and mitochondrial dysfunction play fundamental roles in the
pathogenesis of diabetic retinopathy (DR). However, the interrelationship between the ER …

The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to
retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However …

Loss of photoreceptors in retinal degenerative diseases also impacts the inner retina:
bipolar cell dendrites retract, neurons rewire, and protein expression changes. ON-bipolar …

The term glaucoma encompasses various neurodegenerative eye disorders, among which
the most common is primary open-angle glaucoma (POAG). Recently, the essential role of …

Preterm white matter injury (WMI) is a demyelinating disease with high incidence and
mortality in premature infants. Oligodendrocyte cells (OLs) are a specialized glial cell that …