Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) protein, an epithelial chloride channel expressed in the airways, pancreas, testis …

The advent of Cystic fibrosis transmembrane receptor (CFTR) modulators in 2012 was a
critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that …

There is a limitation in the range of effectual antibiotics due to the Pseudomonas aeruginosa
(PA) infection due to its innate antimicrobial resistance. Researchers have therefore been …

An understanding of chemotaxis at the level of cell–molecule interactions is important
because of its relevance in cancer, immunology, and microbiology, just to name a few. This …

The airways are lined with a film of liquid about 10 µm deep that is in two layers. Around the
cilia is the watery periciliary sol. Over this is a mucous blanket that traps inhaled particles …

The aims of this article are to summarize existing knowledge regarding the pathophysiology
of small airways disease in cystic fibrosis (CF), to speculate about additional mechanisms …

Chronic lung disease remains the major cause of morbidity and mortality of cystic fibrosis
(CF) patients. Cftr mutant mice developed severe intestinal obstruction, but did not exhibit …

Most airway mucus is produced by submucosal glands in response to neural signals. Gland
mucus traps microbes, inhibits their replication, and clears them from the airways. In cystic …

Fluid and macromolecule secretion by submucosal glands in mammalian airways is
believed to play an important role in airway defense and surface liquid homeostasis and in …

Although alteration of airway pH may serve an innate host defense capacity, it also is
implicated in the pathophysiology of obstructive airway diseases. Acid-induced asthma …