Mucociliary transport (MCT) is an innate defense mechanism that removes particulates,
noxious material, and microorganisms from the lung. Several airway diseases exhibit …

Background: Increased hydrogen and reduced chloride ionic environments of the airways
are conducive to the stimulation of cough. However, the constituents of the local milieu of the …

We are testing the hypothesis that the malfunctioning of airway gland serous cells is a
component of cystic fibrosis (CF) airway disease. CF is caused by mutations that disrupt CF …

Cystic fibrosis (CF) is characterized by chronic lung infection and inflammation, with periods
of acute exacerbation causing severe and irreversible lung tissue damage. We used protein …

Loss or dysfunction of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR)
leads to impairment of airway mucus transport and to chronic lung diseases resulting in …

Airway submucosal glands have been proposed as a primary site for initiating and
sustaining airway disease in cystic fibrosis (CF). However, it has been difficult to define the …

Cystic fibrosis (CF) is a lethal, recessive, genetic disease affecting approximately 1 in 2500
live births among Caucasians. The CF gene codes for a cAMP/PKA‐dependent, ATP …

Efficient clearance of mucus and inhaled pathogens from the lung is dependent on an
optimal airway surface liquid (ASL) volume, which is maintained by the regulated transport …

Cystic fibrosis (CF) is characterized by abnormal transepithelial ion transport. However, a
description of CF lung disease pathophysiology unifying superficial epithelial and …

In response to respiratory insults, airway submucosal glands secrete copious mucus strands
to increase mucociliary clearance and protect the lung. However, in cystic fibrosis …