The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of
molecules associated with one of the major pathways through which many cytokines exert …

Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …

Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers
and Activators of Transcription) pathway, play a central role in the pathogenesis of …

As a chronic inflammatory disease, ulcerative colitis has significant negative impact on the
quality of life (QoL) of patients. Since the disease affects many aspects of QoL, comprising …

Fatigue is a burdensome, multidimensional, and multifactorial symptom that is associated
with a wide array of chronic illnesses, specifically occurring in nearly 50% of patients with …

In recent years, better knowledge of the pathophysiology of inflammatory bowel diseases
(IBD) has led to a relevant expansion of the therapeutic arsenal for these conditions. Janus …

Inflammatory bowel diseases, comprising ulcerative colitis (UC) and Crohn's disease, are
chronic, immune-mediated and progressive inflammatory disorders affecting the …

Tofacitinib is an oral small molecule directed against the JAK/STAT pathway, blocking the
inflammatory cascade. Oral formulation of tofacitinib has recently been approved for the …

Background: Treatment of inflammatory bowel diseases (IBD) has tremendously improved
during the last 20 years; however, a substantial fraction of patients does not respond to …