New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation
New series of isoxazole derivatives were synthesized and evaluated for in vitro antitumor
activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a …
activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a …
A new family of densely functionalized fused-benzoquinones as potent human protein kinase CK2 inhibitors
P Martin-Acosta, S Haider, A Amesty, D Aichele… - European Journal of …, 2018 - Elsevier
A new series of 2-amino-4-phenyl-6-hydroxy-7-alkyl-pyranobenzoquinones was
synthesized as ATP-competitive CK2 inhibitors. They were readily synthesized through a …
synthesized as ATP-competitive CK2 inhibitors. They were readily synthesized through a …
[HTML][HTML] QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a …
S Haidar, C Marminon, D Aichele, A Nacereddine… - Molecules, 2019 - mdpi.com
Casein kinase II (CK2) is an intensively studied enzyme, involved in different diseases,
cancer in particular. Different scaffolds were used to develop inhibitors of this enzyme. Here …
cancer in particular. Different scaffolds were used to develop inhibitors of this enzyme. Here …
Development of an in vitro screening assay for PIP5K1α lipid kinase and identification of potent inhibitors
The human phosphatidylinositol 4‐phosphate 5‐kinase type I α (hPIP5K1α) participates in
the phosphoinositide‐3‐kinase/protein kinase B/mammalian target of rapamycin signaling …
the phosphoinositide‐3‐kinase/protein kinase B/mammalian target of rapamycin signaling …
[HTML][HTML] Synthesis and biological evaluation of anthracene-9, 10 dione derivatives as CK2 inhibitors
P López-Rojas, S Haidar, FM Jürgens, D Aichele… - Results in …, 2023 - Elsevier
Human protein kinase CK2 is an important target for the development of anticancer drugs.
Many inhibitors were developed in the last few decades, among them emodin, a natural …
Many inhibitors were developed in the last few decades, among them emodin, a natural …
Synthesis and biological evaluation of novel 2 (4-hydroxynaphthyl) chromen-4-one as a CK2 inhibitor
Protein kinase CK2 is a potential drug target for many diseases including cancer,
inflammatory disorders, Alzheimer's disease, Parkinson's disease and viral infections …
inflammatory disorders, Alzheimer's disease, Parkinson's disease and viral infections …
In silico and in vitro studies of natural compounds as human CK2 inhibitors
S Haidar, F Jürgens, D Aichele… - Current Computer-Aided …, 2021 - ingentaconnect.com
Background: Casein Kinase 2 (CK2) is a ubiquitous cellular serine-threonine kinase with
broad spectrum of substrates. This enzyme is widely expressed in eukaryotic cells and is …
broad spectrum of substrates. This enzyme is widely expressed in eukaryotic cells and is …
[引用][C] Untersuchungen zur Interaktion des Proliferating Cell Nuclear Antigen (PCNA) mit p15 und Identifizierung eines potenten peptidischen Inhibitors
S Hardebeck - 2023 - miami.uni-muenster.de