Type 1 diabetes affects millions of people globally and requires careful management to
avoid serious long-term complications, including heart and kidney disease, stroke, and loss …

Diabetes mellitus has been described as a chronic endocrine and metabolic disease, which
is characterized by hyperglycemia and the coexistence of multiple complications. At present …

Prevalence of type 2 diabetes (T2D) and obesity is increasing worldwide. Currently
available therapies are not suited for all patients in the heterogeneous obese/T2D …

Background Type 1 diabetes mellitus (T1DM) is an autoimmune disorder characterized by T
cell-mediated self-destruction of insulin-secreting islet β cells. Management of T1DM is …

While gene transfer using recombinant adeno-associated viral (rAAV) vectors has shown
success in some clinical trials, there remain many tissues that are not well transduced …

Single-cell molecular tools have been developed at an incredible pace over the last five
years as sequencing costs continue to drop and numerous molecular assays have been …

Type 1 diabetes (T1D) is an autoimmune disease that is generally considered to be T cell-
driven. Accordingly, most strategies of immunotherapy for T1D prevention and treatment in …

Background/objectives During obesity, hypertrophic enlargement of white adipose tissue
(WAT) promotes ectopic lipid deposition and development of insulin resistance. In contrast …

The growth hormone (GH) plays a key role in the regulation of metabolic processes in an
organism. Determination of the correct structure and functioning of the growth hormone …

Diabetes mellitus is a chronic disease of carbohydrate metabolism characterized by
uncontrolled hyperglycemia due to the body's impaired ability to produce or respond to …