Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Antibacterial resistance is a great concern and requires global action. A critical question is
whether enough new antibacterial drugs are being discovered and developed. A review of …

Pseudomonas aeruginosa is one of the six bacterial pathogens, Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

The emergence of antibiotic-resistant bacteria through mutations or the acquisition of
genetic material such as resistance plasmids represents a major public health issue …

Bacteria have evolved numerous means of survival in adverse environments with dormancy,
as represented by “persistence” and the “viable but nonculturable”(VBNC) state, now …

Antibiotic treatment failure is of growing concern. Genetically encoded resistance is key in
driving this process. However, there is increasing evidence that bacterial antibiotic …

A minor population of cancer cells may evade cell death from chemotherapy and targeted
therapy by entering a reversible slow proliferation state known as the drug tolerant persister …

Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tipping point”. Some examples are mass extinctions …

For decades, mankind has dominated the battle against bacteria, yet the tide is slowly
turning. Our antibacterial strategies are becoming less effective, allowing bacteria to get the …

Biocides used as disinfectants are important to prevent the transmission of pathogens,
especially during the current antibiotic resistance crisis. This crisis is exacerbated by …