[HTML][HTML] Astrocytes and microglia as non-cell autonomous players in the pathogenesis of ALS
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that leads
to a progressive muscle wasting and paralysis. The pathological phenotypes are featured by …
to a progressive muscle wasting and paralysis. The pathological phenotypes are featured by …
Stem cell technology for the study and treatment of motor neuron diseases
JS Lunn, SA Sakowski, T Federici, JD Glass… - Regenerative …, 2011 - Future Medicine
Amyotrophic lateral sclerosis and spinal muscular atrophy are devastating
neurodegenerative diseases that lead to the specific loss of motor neurons. Recently, stem …
neurodegenerative diseases that lead to the specific loss of motor neurons. Recently, stem …
Nijmegen breakage syndrome
International Nijmegen Breakage Syndrome … - Archives of Disease in …, 2000 - adc.bmj.com
BACKGROUND Nijmegen breakage syndrome (NBS) is a rare autosomal recessive
disorder. NBS-1, the gene defective in NBS, is located on chromosome 8q21 and has …
disorder. NBS-1, the gene defective in NBS, is located on chromosome 8q21 and has …
The neuroprotective role of creatine
AM Klein, RJ Ferrante - Creatine and Creatine Kinase in Health and …, 2007 - Springer
Significant progress has been made in identifying neuroprotective agents and their
translation to patients with neurological disorders. While the direct causative pathways of …
translation to patients with neurological disorders. While the direct causative pathways of …
Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
progressive paralysis due to motor neuron degeneration. Despite the fact that many different …
progressive paralysis due to motor neuron degeneration. Despite the fact that many different …
Expression of taurine transporter (TauT) is modulated by heat shock factor 1 (HSF1) in motor neurons of ALS
MK Jung, KY Kim, NY Lee, YS Kang, YJ Hwang… - Molecular …, 2013 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive paralysis caused by the degeneration of motor neurons throughout the central …
progressive paralysis caused by the degeneration of motor neurons throughout the central …
Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
degeneration of motor neurons throughout the central nervous system. Mutations of the free …
degeneration of motor neurons throughout the central nervous system. Mutations of the free …
[HTML][HTML] Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
selective degeneration of motor neurons throughout the central nervous systems. Non-cell …
selective degeneration of motor neurons throughout the central nervous systems. Non-cell …
Can selection of rapidly progressing patients shorten clinical trials in amyotrophic lateral sclerosis?
M De Carvalho, M Swash - Archives of neurology, 2006 - jamanetwork.com
Background The marked variability in progression of amyotrophic lateral sclerosis (ALS)
requires large numbers of patients to detect a significant effect in current clinical trial …
requires large numbers of patients to detect a significant effect in current clinical trial …
Nuclear factor‐κb activation is associated with glutamate‐evoked tissue transglutaminase up‐regulation in primary astrocyte cultures
D Caccamo, A Campisi, M Currò… - Journal of …, 2005 - Wiley Online Library
We have previously demonstrated that alterations of cell redox state, evoked by glutamate,
are associated with tissue transglutaminase increases in primary astrocyte cultures …
are associated with tissue transglutaminase increases in primary astrocyte cultures …