The mammalian lung´ s structural design is optimized to serve its main function: gas
exchange. It takes place in the alveolar region (parenchyma) where air and blood are …

Mechanical ventilation is a life-saving therapy in patients with acute respiratory distress
syndrome (ARDS). However, mechanical ventilation itself causes severe co-morbidities in …

Oxygen is toxic across all three domains of life. Yet, the underlying molecular mechanisms
remain largely unknown. Here, we systematically investigate the major cellular pathways …

Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of
cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous …

In the field of X-ray microcomputed tomography (μCT) there is a growing need to reduce
acquisition times at high spatial resolution (approximate micrometers) to facilitate in vivo and …

Synchrotron X-rays can be used to obtain highly detailed images of parts of the lung.
However, micro-motion artifacts induced by such as cardiac motion impede quantitative …

Within the pulmonary acini ventilation and blood perfusion are brought together on a huge
surface area separated by a very thin blood-gas barrier of tissue components to allow …

Phase-contrast X-ray lung imaging has broken new ground in preclinical respiratory
research by improving contrast at air/tissue interfaces. To minimize blur from respiratory …

X-ray computed tomography of small animals and their organs is an essential tool in basic
and preclinical biomedical research. In both phase-contrast and absorption tomography …

Abstract Computational Fluid Dynamics (CFD) have offered an attractive gateway to
investigate in silico respiratory flows and aerosol transport in the depths of the lungs. Yet, not …